Monday, October 23, 2023
Wednesday, October 18, 2023
Excess Positivity???
Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio.[2]
Dimenhydrinate was introduced to the market by G.D. Searle in 1949.[3][4]
Medical uses[edit]
Dimenhydrinate is an over-the-counter (OTC) antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea.[2]
Side effects[edit]
Common side effects may include:[5]
- Drowsiness
- Dry mouth, nose, or throat
- Constipation
- Blurred vision
- Feeling restless or excited (especially in children)
Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk of cognitive decline and dementia in older people.[6][7]
Pharmacology[edit]
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main differences relative to pure diphenhydramine are a lower potency due to being combined with 8-chlorotheophylline (by weight, dimenhydrinate is between 53% and 55.5% diphenhydramine)[8] and the fact that the stimulant properties of 8-chlorotheophylline help reduce the side effect of drowsiness brought on by diphenhydramine. Diphenhydramine is itself an H1 receptor antagonist that demonstrates anticholinergic activity.[9]
Pharmacokinetics[edit]
The diphenhydramine component requires about 2 hours to reach peak concentration after either oral or sublingual administration of diphenhydrinate, and has a half-life of 5 – 6 hours in healthy adults.[1]
Recreational use[edit]
Dimenhydrinate is recreationally used as a deliriant.[10][11][12] Slang terms for Dramamine used this way include "drama", "dime", "dime tabs", "D-Q", "substance D", "d-house", and "drams".[13] Abusing Dramamine is sometimes referred to as Dramatizing or "going a dime a dozen", a reference to the amount of Dramamine tablets generally necessary for a trip.[14]
Many users report a side-effect profile consistent with tropane alkaloid (e.g. atropine) poisoning as both show antagonism of muscarinic acetylcholine receptors in both the central and autonomic nervous system, which inhibits various signal transduction pathways.[11]
Other CNS effects occur within the limbic system and hippocampus, causing confusion and temporary amnesia due to decreased acetylcholine signaling. Toxicology also manifests in the autonomic nervous system, primarily at the neuromuscular junction, resulting in ataxia and extrapyramidal side effects and the feeling of heaviness in the legs, and at sympathetic post-ganglionic junctions, causing urinary retention, pupil dilation, tachycardia, irregular urination, and dry red skin caused by decreased exocrine gland secretions, and mucous membranes. Considerable overdosage can lead to myocardial infarction (heart attack), serious ventricular arrhythmias, coma, and death.[15] Such a side effect profile is thought to give ethanolamine-class antihistamines a relatively low abuse liability.[citation needed] An antidote that can be used for dimenhydrinate poisoning is physostigmine.[16]
History[edit]
Dimenhydrinate (then known as Compound 1694) was being tested as a potential treatment for hay fever and hives at Johns Hopkins Hospital in 1947 by allergists Dr. Leslie Gay and Dr. Paul Carliner. Among those who received the drug was a pregnant woman who had suffered from motion sickness her entire life. She remained symptom-free if she took dimenhydrinate a few minutes before boarding a trolley, whereas the placebo was ineffective. To confirm these findings, the following year, G.D. Searle & Co. conducted a trial in which dimenhydrinate or placebo was given to U.S. troops crossing the Atlantic during "a rough passage" in a converted freight ship, the General Ballou, for 10 days as a rescue therapy for sea sickness. The findings were positive, as were the findings of a second trial of mostly women on the ship's return voyage. Gay and Carliner announced their discovery at a meeting of the Johns Hopkins Medical Society on February 14, 1949, as well as in the Bulletin of The Johns Hopkins Hospital. The New York Times, the Baltimore Sun, and other national newspapers covered the discovery, and Dramamine was made available in drugstores later that year.[3][4][17]
Brand names[edit]
Dimenhydrinate is marketed under many brand names: in the U.S., Mexico, Turkey, Serbia, and Thailand as Dramamine; in Ukraine as Driminate; in Canada, Costa Rica, and India as Gravol; in Iceland as Gravamin; in Russia and Croatia as Dramina; in South Africa and Germany as Vomex; in Australia and Austria as Vertirosan; in Brazil as Dramin; in Colombia as Mareol; in Ecuador as Anautin; in Hungary as Daedalon; in Indonesia as Antimo; in Italy as Xamamina or Valontan; in Peru as Gravicoll; in Poland and Slovakia as Aviomarin;[18] in Portugal as Viabom, Vomidrine, and Enjomin; in Spain as Biodramina; in Israel as Travamin; and in Pakistan as Gravinate.[19]
Popular culture[edit]
Modest Mouse produced a song titled "Dramamine" on their 1996 debut album This Is a Long Drive for Someone with Nothing to Think About. The song uses side effects of the drug as a metaphor for the deteriorating state of a personal relationship.[20]
Saturday, October 14, 2023
Saturday, October 7, 2023
Friday, October 6, 2023
Free to Decide
On 15 January 2018, O'Riordan was found unresponsive in the bathroom of her London hotel room, and was pronounced dead at 9:16 a.m. She was 46.[304][305] An inquest at Westminster Coroner's Court held on 6 September,[306][307] ruled that she died as a result of accidental drowning in a bath following sedation by alcohol intoxication.[306][308] Empty bottles were found in O'Riordan's room (five miniature bottles and a champagne bottle) as well as some prescription drugs. Toxicology tests showed that her body contained only "therapeutic" levels of these medications but a blood alcohol content of 330 mg/dL (0.33%).[306][308]
O'Riordan lived in New York City at the time. She had travelled to London to work with Martin "Youth" Glover on her side-project D.A.R.K. and to meet representatives of the BMG record label about a new Cranberries album.[309][310][311] O'Riordan arrived at the Hilton Hotel on Park Lane, Mayfair, on 14 January.[304] At 2 a.m. on 15 January 2018, O'Riordan had a phone call with her mother.[312] It was later that morning that she was found and pronounced dead.
The day after her death, the tabloid newspaper Santa Monica Observer spread a false story that fentanyl had been found in the room, indicating that London authorities suspected suicide and a "deliberate overdose".[313] The fentanyl overdose rumour endured for months.[314]
The cause of death was not made public for about nine months, until the Westminster inquest.